The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD

Not Applicable

Recruiting

• Conditions: PTSD

• Registration Number: NCT06144203
• Lead Sponsor: University of Alabama, Tuscaloosa

Brief Summary

This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-11-16
• Study First Submitted QC: 2023-11-16
• Study First Posted: 2023-11-22
• Study Start: 2024-01-29
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-13
• Last Update Posted: 2024-02-15
• Primary Completion: 2029-03
• Study Completion: 2029-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Skin conductance responses	Collected during fear conditioning, fear extinction, and extinction recall task.	SCR data will be collected while participants are completing the cognitive task in the MRI environment.
Threat expectancy ratings	Collected during fear conditioning, fear extinction, and extinction recall task.	Threat expectancy ratings will be collected while participants are completing the cognitive task in the MRI environment.
Neural activity	Collected during fear conditioning, fear extinction, and extinction recall task.	Neural activity will be collected while participants are completing the cognitive task in the MRI environment.

Trial Locations

Locations (1)

Wade Hall - University of Alabama; 🇺🇸 Tuscaloosa, Alabama, United States