The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD
- Conditions
- PTSD
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT06144203
- Lead Sponsor
- University of Alabama, Tuscaloosa
- Brief Summary
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Moderate-intensity aerobic exercise Exercise - High-intensity aerobic exercise Exercise - Light-intensity aerobic exercise Exercise -
- Primary Outcome Measures
Name Time Method Skin conductance responses Collected during fear conditioning, fear extinction, and extinction recall task. SCR data will be collected while participants are completing the cognitive task in the MRI environment.
Threat expectancy ratings Collected during fear conditioning, fear extinction, and extinction recall task. Threat expectancy ratings will be collected while participants are completing the cognitive task in the MRI environment.
Neural activity Collected during fear conditioning, fear extinction, and extinction recall task. Neural activity will be collected while participants are completing the cognitive task in the MRI environment.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Wade Hall - University of Alabama
🇺🇸Tuscaloosa, Alabama, United States