Register for Longitudinal Recording of Brain Function in Patients With Brain Diseases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- cortical data
研究概览
简要总结
The aim of this observational register study is to establish a registry that completely records and compiles the data from routinely performed technical examinations (navigated transcranial magnetic stimulation, intraoperative neuromonitoring and stimulation, MRI imaging including tractography and connectome) and clinical tests over time (pre-, intra- and postoperative, under adjuvant therapy, as part of follow-up care) of patients with intracranial masses and lesions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intracranial lesion
- •Age ≥ 18 years
- •Written consent to participate in the study
排除标准
- •Age < 18 years
- •Patients not able to give consent
- •Patients with intracranial ferromagnetic metal implants
- •Patients with implanted electronic devices
结局指标
主要结局
cortical data
时间窗: until last patient FU up to 48 months
cortical nTMS-Data - distribution according the cortical parellation system
Cognitive status
时间窗: until last patient FU up to 48 months
Higher cognitive functions - determined by the Montreal Cognitive Assessment (MocA)
Motor status
时间窗: until last patient FU up to 48 months
Motor function according to the BMRC scale
Fiber tracts
时间窗: until last patient FU up to 48 months
fractional anisotropy of fiber tracts
structural imaging (Connectome)
时间窗: until last patient FU up to 48 months
characteristics of Connectome and Disconnectome analysis (Global Efficiency value)
Language status
时间窗: until last patient FU up to 48 months
Language function tested by the Aphasia Check List
次要结局
未报告次要终点
研究者
Schwendner Maximilian
Principal Investigator
University Hospital Heidelberg