A longitudinal multimodal investigation of postpartum neuroplasticity and the attendant risk and modulatory factors

Recruiting

Conditions: F53.0
F53.1
Mild mental and behavioural disorders associated with the puerperium, not elsewhere classified
Severe mental and behavioural disorders associated with the puerperium, not elsewhere classified

Registration Number: DRKS00029174

Lead Sponsor: niklinik RWTH AachenKlinik für Psychiatrie, Psychotherapie und Psychosomatik

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 86

Inclusion Criteria

Pregnant or postpartum women: healthy, full-term primiparous pregnancy (> 37 weeks gestation).
Nulliparous women: age-matched with postpartum women, never been pregnant regardless of pregnancy outcome (e.g., extrauterine pregnancy or spontaneous abortion)

Exclusion Criteria

All participants: no alcohol or psychotropic substance dependence or use (during pregnancy), no acute depression or depression (during pregnancy), no acute or previous psychosis or manic episodes.

Postpartum women: Mothers of infants who are in the intensive care unit after delivery.

MRI: pacemaker or implantable defibrillator; plates, pins, screws, or metal mesh used to repair bones or joints; metal implants; metal jewelry, including an implanted or external drug pump; epilepsy; or claustrophobia

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Model of the peri- and postpartum brain starting at time from childbirth: structural and functional plasticity in the postpartum period and investigating if and when the maternal brain returns to its pre-pregnancy state (comparison with nulliparous women).

Secondary Outcome Measures

Name	Time	Method
Model of postpartum neuroplasticity and associated risk and modulating factors (physical health, hormones) and their impact on infant attachment and cognitive performance.