Antigen-specific Immune Response to Hepatitis B Virus and Influenza A (H1N1 Strain) in Utero
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Anti - viral immune response in cord blood of newborn infants born to HBV+ mothers
研究概览
简要总结
This study aims to gain an understanding of the key components of the immune response to hepatitis B present in cord blood of HBV infected mothers.
详细描述
Despite the development of an effective preventive HBV vaccine, the spread of HBV virus continue, particularly in Asia, where the majority of HBV infection is acquired at birth by vertical transmission from mother to baby. HBV vertical transmission has been hypothesized to cause immune tolerance to HBV and thus promoting the subsequent HBV chronicity. Such hypothesis has never been tested and nothing is known about HBV-specific adaptive immune response occurring before birth in baby born form HBV chronically infected mothers. This study aims to gain an understanding of the key components of the immune response to hepatitis B present in cord blood of HBV infected mothers. The characterization of the HBV immune response in utero will provide informations about the cause of HBV chronicity in Asian patients in the management of baby born from HBsAg+ mothers.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women with HBsAg+
排除标准
- •Pregnant women without HBsAg+
结局指标
主要结局
Anti - viral immune response in cord blood of newborn infants born to HBV+ mothers
时间窗: At birth (baseline)
Immune response was defined as activation of innate immune effectors (NK cells, monocytes) and production of TH1 cytokines IL - 2, TNF - a and IFN - g from T cells.
次要结局
- Expression of immune genes from immune cells(At birth (baseline))
研究者
Obstetrics & Gynaecology
Associate Professor Chong Yap Seng
National University Hospital, Singapore