Trial of the Use of Doxycycline After Rotator Cuff Repair
- Registration Number
- NCT02388477
- Lead Sponsor
- Milton S. Hershey Medical Center
- Brief Summary
The purpose of this study is to examine healing after rotator cuff repair in subjects either treated with Doxycycline or placebo post-operatively.
- Detailed Description
Basic Science small animal model data indicates that matrix metalloproteinase (MMP) inhibition via doxycycline results in improved early rotator cuff repair biomechanics and histology. Rotator cuff repair failure and retear is a significant clinical problem. The effects of MMP inhibition on human rotator cuff tear repair healing and outcomes is unknown, but may potentially improve healing rates and outcomes. Our purpose is to evaluate the effects of early oral doxycycline on healing and outcomes following arthroscopic rotator cuff repair.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- repair of rotator cuff
- age 18 and above
- able to swallow capsules
- less than 18
- unable to read or understand consent form
- unable to swallow capsules
- allergy to doxycycline
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sugar pill sugar pill sugar pill, same size, shape, and color as comparator, twice a day for 2 weeks. Doxycycline Doxycycline oral doxycycline, 2 weeks, twice a day,
- Primary Outcome Measures
Name Time Method rotator cuff ultrasound of post-operative shoulder one year An ultrasound of the post-operative rotator cuff to assess level of healing or defect present.
- Secondary Outcome Measures
Name Time Method American Shoulder and Elbow Surgeons score 6 weeks, 3mos, 6mos, 1yr and 2 yr. The survey is a standardized assessment of shoulder pain and function from the patient's perspective.
Trial Locations
- Locations (1)
Penn State Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States