Biomolecular and histopathological evaluation of fat and muscle tissue in patients with obstructive sleep apnea

Not Applicable

Recruiting

• Conditions: Sleep apnoea; Obesity due to excess calories

• Registration Number: RBR-2qknq6d
• Lead Sponsor: niversidade Federal de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-02-11
• Study Completion: 2021-12-20
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients diagnosed with obesity; indication for bariatric surgery; eutrophic patients with indication for cholecystectomy; aged over 18 and under 50 years old; both sexes; with body mass index greater than or equal to 40 or 35 with compensated comorbidities; BMI between 20 and 29.9 for the eutrophic control group.

Exclusion Criteria

Individuals who present the usual report of sleep time less 4 hours per night; individuals with insomnia; shift workers; chronic alcoholism; use of neuroleptic and hypnotic drugs; psychiatric diseases; individuals with locomotion; individuals using drugs that inhibit autophagy such as colchicine and bafilomycin.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To verify changes in the adaptive capacity of skeletal muscle and adipose tissue, considering the autophagic tissue flow through biochemical and histopathological analyzes of the adipose and muscle tissues collected through biopsy.

Secondary Outcome Measures

Name	Time	Method
Correlate changes in the adaptive capacity of skeletal muscle and adipose tissue, considering the autophagic tissue flow assessed by biochemical and histopathological analyzes of adipose and muscle tissues with the associated comorbidities in the study population, for example, insulin resistance and diabetes mellitus type 2