KCT0000847
Completed
未知
The study analyzing blood and cerebrospinal fluids from the patients with early onset Alzheimer disease to discover causative factors and biomarkers
Soon Chun Hyang University Hospital Bucheon0 sites516 target enrollmentTBD
ConditionsDiseases of the nervous system
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Diseases of the nervous system
- Sponsor
- Soon Chun Hyang University Hospital Bucheon
- Enrollment
- 516
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)Disease group: The patients who develop AD or MCI before 65 year\-old
- •2\)Control 1 (normal control or first degree family member of AD patient ): The normal persons who have normal neuroimaging (on Brain CT or Brain MRI) and cognitive functions or the first degree senior family member of AD patients.
- •3\)Control 2 (sporadic AD senile patients): The patients who develop AD after 65 year\-old, but do not have first degree family history of AD.
- •Alzheimer's disease is diagnosed based on the followings,
- •1\) Dementia by DSM\-IV
- •2\) Probable AD by NINCDS\-ADRDA
- •3\) Slowly progressive cognitive decline, at least for 6 months
- •4\) Presence of one of the followings according to the revised NINCDS\-ADRDA criteria
- •?Atrophy of medial temporal and/or parietal lobe on MRI,
- •?Hypometabolism in medial temporal and/or parietal lobe on FDG\-PET, or increased uptake in the same area on amyloid PET
Exclusion Criteria
- •1\) Blindness or hearing loss to be unable to be tested
- •2\)sick\-sinus syndrome, a second or third degree atrioventricular block
- •3\)severe pulmonary disease (acute, severe, or unstable asthma, severe COPD)
- •4\)an active gastric ulcer
- •5\)uncontrolled diabetes mellitus
- •6\)severe hepatic, or renal disease
- •7\)uncured malignancy
- •8\)major depressive disorder, psychosis
- •9\)mental retardation
- •10\)a history of encephalitis
Outcomes
Primary Outcomes
Not specified
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