KCT0000847已完成未知
The study analyzing blood and cerebrospinal fluids from the patients with early onset Alzheimer disease to discover causative factors and biomarkers
Soon Chun Hyang University Hospital Bucheon0 个研究点目标入组 516 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 516
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational Study
入排标准
- 年龄范围
- o Limit 至 o Limit（—）
- 性别
- All
入选标准
- •1)Disease group: The patients who develop AD or MCI before 65 year-old
- •2)Control 1 (normal control or first degree family member of AD patient ): The normal persons who have normal neuroimaging (on Brain CT or Brain MRI) and cognitive functions or the first degree senior family member of AD patients.
- •3)Control 2 (sporadic AD senile patients): The patients who develop AD after 65 year-old, but do not have first degree family history of AD.
- •Alzheimer's disease is diagnosed based on the followings,
- •1) Dementia by DSM-IV
- •2) Probable AD by NINCDS-ADRDA
- •3) Slowly progressive cognitive decline, at least for 6 months
- •4) Presence of one of the followings according to the revised NINCDS-ADRDA criteria
- •?Atrophy of medial temporal and/or parietal lobe on MRI,
- •?Hypometabolism in medial temporal and/or parietal lobe on FDG-PET, or increased uptake in the same area on amyloid PET
- •MCI is diagnosed based on the followings,
- •1) No dementia or normal
- •2) Memory complaint by subject or study partner
- •3) Objective cognitive impairment
- •4) Preserved activities of daily living
- •Normal is diagnosed based on the followings,
- •1)No dementia or MCI
- •2)No significant brain atrophy or other abnormalities in CT or MRI
排除标准
- •1) Blindness or hearing loss to be unable to be tested
- •2)sick-sinus syndrome, a second or third degree atrioventricular block
- •3)severe pulmonary disease (acute, severe, or unstable asthma, severe COPD)
- •4)an active gastric ulcer
- •5)uncontrolled diabetes mellitus
- •6)severe hepatic, or renal disease
- •7)uncured malignancy
- •8)major depressive disorder, psychosis
- •9)mental retardation
- •10)a history of encephalitis
- •11)head trauma with loss of consciousness longer than one hour
- •12)a brain tumor, a traumatic intracranial hemorrhage or a subarachnoid hemorrhage
- •13) abnormal TFT
- •14) a deficiency in vitamin B12 or folate
- •15) neurosyphilis
- •16)metabolic encephalopathy
研究者
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