Are Neuroticism, Perceived Stress, and Adverse Life Events Risk Factors for Functional Somatic Disorders: DanFunD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7,493
- 主要终点
- Irritable bowel at 5-year follow-up
研究概览
简要总结
The objective of this study is to explore the role of neuroticism, perceived stress, and adverse life events, respectively, in the development and perpetuation of functional somatic disorders.
详细描述
Functional somatic disorders (FSD) are common disorders with a multifactorial aetiology involving biological, social, and psychological factors. An often used explanation of the illness mechanisms behind FSD which is provided to the patients is, that FSD may be understood as a multi systemic physical response to stress. This relationship can be modelled as proposed in the Cognitive Behavioural Therapy (CBT) model of emotional distress where several cognitive, behavioural and psychological factors are thought to contribute to the onset and perpetuation of FSD. Personality traits e.g. neuroticism contribute to give rise to our cognitive, behavioural, and psychological reactions. Furthermore, neuroticism with its heightened reactivity to stressors, has shown to be an important predictor of a generic vulnerability to both physical and psychological conditions. Having been exposed to previous adverse life events/traumas and childhood adversities has also showed to impact the risk of having FSD. This relationship has been proposed to be induced by a heightened response to stimuli, i.e. sensitisation, caused by physical and emotional distress triggering a hormonal cascade in the hypothalamus pituitary adrenal (HPA) axis.
So far, most studies into these aspects have been carried out in selected patient samples, and general population-based studies including a large randomly obtained sample are sparse. In three recent population-based studies, strong associations between FSD and neuroticism, perceived stress, and the accumulated number of experienced adverse life events (ALE), respectively, have been established. However, these studies were cross-sectional, thereby not providing insight to whether these factors were risk factors of FSD. More studies are needed for further elucidation on these aspects.
Objective The objective of this study is to explore the role of neuroticism, perceived stress, and the accumulated number of ALE, respectively, in the development and perpetuation of FSD.
Hypotheses
- Higher neuroticism, higher perceived stress, and higher number of ALE at baseline are individual risk factors of having developed FSD in the 5-year period from baseline to follow-up:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Not born in Denmark
- •Not being a Danish citizen
- •Pregnancy
结局指标
主要结局
Irritable bowel at 5-year follow-up
时间窗: At the DanFunD 5-year follow-up investigation
Participants fulfilling the diagnostic criteria for irritable bowel will be identified with self-reported questionnaires
Irritable bowel at baseline
时间窗: At the DanFunD baseline investigation
Participants fulfilling the diagnostic criteria for irritable bowel will be identified with self-reported questionnaires
Questionnaire-defined Functional somatic disorder at baseline
时间窗: At the DanFunD baseline investigation
Participants fulfilling the diagnostic criteria of the unifying diagnostic concept Bodily Distress Syndrome single- and multi-organ type will be defined with self-reported questionnaires.
Questionnaire-defined Functional somatic disorder at 5-year follow-up
时间窗: At the DanFunD 5-year follow-up investigation
Participants fulfilling the diagnostic criteria of the unifying diagnostic concept Bodily Distress Syndrome single- and multi-organ type will be defined with self-reported questionnaires.
Interview-based Functional somatic disorder at 5-year follow-up
时间窗: At the DanFunD 5-year follow-up investigation
Participants fulfilling the diagnostic criteria of the unifying diagnostic concept Bodily Distress Syndrome single- and multi-organ type will be defined with diagnostic interviews.
Chronic widespread pain at baseline
时间窗: At the DanFunD baseline investigation
Participants fulfilling the diagnostic criteria for chronic widespread pain will be identified with self-reported questionnaires
Chronic fatigue at baseline
时间窗: At the DanFunD baseline investigation
Participants fulfilling the diagnostic criteria for chronic fatigue will be identified with self-reported questionnaires.
Interview-based Functional somatic disorder at baseline
时间窗: At the DanFunD baseline investigation
Participants fulfilling the diagnostic criteria of the unifying diagnostic concept Bodily Distress Syndrome single- and multi-organ type will be defined with diagnostic interviews.
Chronic widespread pain at 5-year follow-up
时间窗: At the DanFunD 5-year follow-up investigation
Participants fulfilling the diagnostic criteria for chronic widespread pain will be identified with self-reported questionnaires.
Chronic fatigue at 5-year follow-up
时间窗: At the DanFunD 5-year follow-up investigation
Participants fulfilling the diagnostic criteria for chronic fatigue will be identified with self-reported questionnaires.
次要结局
未报告次要终点