High Flow Oxygen With THRIVE Gives Better Oxygenation in Rapid Sequence Induction Patients

Not Applicable

• Conditions: Airway Morbidity; High Flow Oxygen in Rapid Sequence Induction
• Interventions: Device: face mask oxygen; Device: High flow oxygen

• Registration Number: NCT02777840
• Lead Sponsor: St George's, University of London

Brief Summary

High flow oxygen results in better oxygenation in emergency cases needing rapid sequence induction for anaesthesia. Secondary outcome measure is time for any desaturation.

Detailed Description

The investigators intend to do the study using high flow oxygen for all emergency cases needing rapid sequence induction. As part of the study the Investigators will measure the oxygen levels in the blood gas sample of the patient and the heart rate of anesthetist in charge of the airway management. After the airway is secured the time for desaturation will be noted.

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2016-05-13
• Study First Submitted QC: 2016-05-18
• Study First Posted: 2016-05-19
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-03
• Last Update Posted: 2017-10-05
• Primary Completion: 2018-03
• Study Completion: 2018-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Emergency patients needing rapid sequence induction for surgery
• ≥ 16 years
• Able to give consent

Exclusion Criteria

• Patients age under 16 years
• Inability to give consent
• Severe respiratory disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Face mask group	face mask oxygen	Patients will be given oxygen via face mask as per routine practice, blood gas sample taken after airway is secured, heart rate of anaesthetist monitored and time for desaturation noted.
THRIVE group	High flow oxygen	Patients will be given oxygen via high flow oxygen in Optiflo, blood gas sample taken after airway is secured, heart rate of anaesthetist monitored and time for desaturation noted.

Primary Outcome Measures

Name	Time	Method
Oxygen levels in blood gas sample	intraoperative	Oxygen levels in blood gas sample after the airway is secured

Secondary Outcome Measures

Name	Time	Method
heart rate of anaesthetist performing the intubation	During the process of induction of anaesthesia and intubation upto 5 minutes post intubation
time to desaturation	intraoperative or 10 minutes after intubation	after airway is secured time will be noted for oxygen levels to fall to 92% before the ventilation is started.

Trial Locations

Locations (1)

St Georges Hospital NHS Trust; 🇬🇧 London, United Kingdom