Combination of Preoperative Gabapentin and TAP Blocks in Decreasing Postoperative Pain

Phase 4

Withdrawn

• Conditions: Postoperative Pain
• Interventions: Procedure: TAP Block; Drug: Gabapentin

• Registration Number: NCT02927405
• Lead Sponsor: State University of New York - Downstate Medical Center

Brief Summary

There is an increasing trend on decreasing narcotic use and maximizing efficiency in the perioperative care. There are no studies that have compared a TAP block versus a TAP block plus gabapentin for laparoscopic procures.This study will investigate if taking gabapentin and receiving a TAP block decrease post-operative morphine consumption. It will be a randomized controlled, double blind study, with 130 patients between 18-60 years; that will undergo laparoscopic GYN procedures. Secondary outcomes will look at the incidence of nausea, vomiting, and VAS (verbal analog scale) scores. This combination may be helpful because gabapentin will be used to decrease visceral and central pain, and TAP block will decrease somatic pain. Performing a multimodal approach may decrease narcotic consumption, adverse effects and improve pain management.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-10-05
• Study First Submitted QC: 2016-10-06
• Study First Posted: 2016-10-07
• Study Start: 2020-03-04
• Primary Completion: 2020-03-31
• Study Completion: 2020-03-31
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-20
• Last Update Posted: 2021-05-25

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• female
• receiving laparoscopic GYN procedure
• between 18-60

Exclusion Criteria

• are already taking gabapentin
• have diabetic neuropathy
• have a chronic pain syndrome
• take opioids at home
• are pregnant
• have kidney disease
• have an allergy to morphine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TAP Block plus placebo	TAP Block	Patients will only receive a TAP block procedure and then morphine consumption will be recorded.
TAP Block plus gabapentin	TAP Block	Patients will receive a TAP block procedure and take pre-operative oral Gabapentin and morphine consumption will me recorded after surgery.
TAP Block plus gabapentin	Gabapentin	Patients will receive a TAP block procedure and take pre-operative oral Gabapentin and morphine consumption will me recorded after surgery.

Primary Outcome Measures

Name	Time	Method
Post-operative morphine consumption	24 hours after surgery.	Total amount of morphine the patient need to control post-operative pain

Secondary Outcome Measures

Name	Time	Method
VAS Scores	24 hours after surgery	Visual analog scale that rates a patient's pain

Trial Locations

Locations (1)

SUNY Downstate Medical Center; 🇺🇸 Brooklyn, New York, United States