Refining Adjuvant treatment IN endometrial cancer Based On molecular features, TransPORTEC platform trials – p53abn - REDRandomized phase III trial testing maintenance olaparib versus observation after adjuvant chemoradiation for p53abn endometrial cancer
- Conditions
- Patients with a histological diagnosis of p53abn HREC, treated with curative intent, after surgery (hysterectomy and bilateral salpingooophorectomy, with or without lymphadenectomy or sentinel node biopsy), without signs of residual disease or distant metastasesTherapeutic area: Not possible to specify
- Registration Number
- CTIS2023-503886-44-00
- Lead Sponsor
- Institut Gustave Roussy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 150
Histologically confirmed diagnosis of EC (all grades and the following histologic subtypes : endometrioid, serous, clear cell, de- /undifferentiated carcinomas, and uterine carcinosarcoma)., WHO Performance score 0-1, Histologically confirmed Stage I to III EC with myometrial invasion, Molecular classification: p53abn EC*, Body weight > 30 kg, Adequate systemic organ function: Patients must have normal organ and bone marrow function measured within 28 days prior to administration of study treatment as defined below: ? Creatinine clearance (> 50 cc/min): Patients must have creatinine less than 1.5 ULN or calculated creatinine clearance estimated of = 51 mL/min using the Cockcroft-Gault equation or based on a 24 hour urine test. Estimated creatinine clearance = (140-age [years]) x weight (kg) (x F) / serum creatinine (mg/dL) x 72 ? Adequate bone marrow function : hemoglobin =10.0 g/dl with no blood transfusion in the past 28 days, Absolute neutrophil count (ANC) =1.5 x 109/l, platelet count = 100 x 109/l. ? Adequate liver function: ? bilirubin =1.5 x institutional upper limit of normal (ULN). This will not apply to patients with confirmed Gilbert’s syndrome (persistent or recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis or hepatic pathology), who will be allowed only in consultation with their physician. ? ALT (SGPT) and/or AST (SGOT) =2.5 x ULN, Molecular classification must be performed according to the diagnostic algorithm presented in the WHO 2020 (Vermij et al. 2020). For the p53abn-RED trial this means that MMR and POLE status must be determined, and must be pMMR and POLE wildtype (or non-pathogenic) for inclusion. For details on the molecular classification see 7.1: Diagnostic algorithm for molecular classification, Patient should understand, sign, and date the written informed consent form prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol., Patients must be affiliated to a social security system or beneficiary of the same, Molecular classification performed following the diagnostic algorithm described in WHO 2020 (adapted from Vermij et al.), TLH-BSO or TAH-BSO with or without lymphadenectomy or sentinel node biopsy, without macroscopic residual disease after surgery, No distant metastases as determined by pre-surgical or postsurgical imaging (CT scan of chest, abdomen and pelvis or PETCT scan), Written informed consent prior to any study specific procedures, Age >= 18 years, Patients must have a life expectancy = 16 weeks, Patients must be accessible for treatment and follow-up, Written informed consent for one of the RAINBO trials and the overarching research project according to the local Ethics Committee requirements
Other malignancy unless curatively treated with no evidence of disease for =5 years except: adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS), Stage 1, grade 1 endometrial carcinoma. Patients with a history of localised triple negative breast cancer may be eligible, provided they completed their adjuvant chemotherapy more than three years prior to registration, and that the patient remains free of recurrent or metastatic disease., Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent., Patient with severe hepatic impairment, Any previous treatment with a PARP inhibitor, including olaparib, History of active primary immunodeficiency, History or evidence of hemorrhagic disorders within 6 months prior to randomization, Patients with myelodysplastic syndrome/acute myeloid leukemia history or with features suggestive of MDS/AML., Previous allogenic bone marrow transplant or double umbilical cord blood transplantation (dUCBT), Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and TB testing in line with local practice), hepatitis B (known positive HBV surface antigen (HBsAg) result), hepatitis C, or human immuno-deficiency virus (positive HIV 1/2 antibodies). Patients with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody [anti-HBc] and absence of HBsAg) are eligible. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA., Concomitant use of known strong CYP3A inhibitors (eg. itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (eg. ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout period prior to starting olaparib is 2 weeks, Concomitant use of known strong (eg. phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John’s Wort) or moderate CYP3A inducers (eg. bosentan, efavirenz, modafinil). The required washout period prior to starting olaparib is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents., FIGO Stage IV disease of any histology even if there is no evidence of disease after surgery, Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the study medication, Medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent., Patient under guardianship or deprived of his liberty by a judicial or administrative decision or incapable of giving its consent, Patients with a known hypersensitivity to olaparib or any of the excipients of the product., Treatment with an unlicensed or investigational
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method