The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Not Applicable
Completed
- Conditions
- Spinal Surgery
- Registration Number
- NCT01855542
- Lead Sponsor
- Yonsei University
- Brief Summary
Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance and metabolic acidosis in critically ill patients. The aim of this investigation is to compare the influence of 0.9% saline and plasmalyte solution on acid-base balance and electrolytes in healthy patients undergoing major spine surgeries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1.50 patients (aged 20-65) undergoing cervical or lumbar spine surgery who were diagnosed spinal stenosis involving more than tow spinal levels.
Exclusion Criteria
- ASA class III or IV
- pregnancy
- breast feeding
- lack of mental weakness(including disabled)
- using diuretics
- respiratory insufficiency
- metabolic acidosis or alkalosis
- coagulation disorder
- over hydtration
- renal failure or serum creatinine > 1.4mg/dl
- anemia (Hemoglobin 9.0<mg/dl)
- hypernatremia (Na > 145mEq/L)
- Hyperkalemia (K>5.5mEq/L)
- psychological medication or any drugs that influences renal clearance
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method base-excess Change from baseline in base-excess at postoperative 12 h
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine🇰🇷Seoul, Korea, Republic of