Inspiratory muscle training in people with Huntington's disease

Completed

• Conditions: Huntington's disease; Nervous System Diseases; Huntington disease

• Registration Number: ISRCTN90741776
• Lead Sponsor: Cardiff University (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02-26
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Age > 18, either sex
2. Genetically confirmed HD
3. Capacity to give informed consent
4. Inspiratory muscle strength < 80% predicted for age and height
5. Maintenance of a stable medical regime for 4 weeks prior to initiation of study

Exclusion Criteria

1. History of additional prior neurological condition, such as stroke
2. Uncontrolled psychiatric symptoms
3. History of spontaneous pneumothorax / unstable asthma / chronic respiratory condition

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inspiratory muscle strength, measured using sniff nasal inspiratory pressure at baseline and end of training.

Secondary Outcome Measures

Name	Time	Method
1. Inspiratory muscle strength, measured using maximal inspiratory pressure at baseline and end of training <br>2. Cough strength, measured by peak cough flow at baseline and end of training <br>3. Functional activity, measured by 30 second sit to stand at baseline and end of training