ISRCTN56366401
Completed
N/A
Platelet Responsiveness and Outcome from Platelet Transfusion - does inherent variation in donor platelet function affect the clinical efficacy of apheresis platelets? A randomised double blind single centre trial.
HS Blood and Transplant [NHSBT] (UK)0 sites130 target enrollmentNovember 19, 2012
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- ational Cancer Research Network, Blood
- Sponsor
- HS Blood and Transplant [NHSBT] (UK)
- Enrollment
- 130
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age 16 years or older
- •2\. Stable Haematology/Oncology Patients at Addenbrooke?s Hospital
- •3\. Thrombocytopenia secondary to bone marrow failure, requiring platelet transfusions according to local and British Committee for Standards in Haematology (BCSH) Guidelines
- •4\. Patients who, if peripheral venous access for blood sampling is required, have adequate access and will consent to their blood being taken in this way
- •5\. Patients able to give written informed consent
- •6\. Male or female
Exclusion Criteria
- •1\. Inherited or acquired clotting disorders
- •2\. Inherited or acquired platelet function disorders
- •3\. Current Acute Promyelocytic Leukaemia
- •4\. Previously documented WHO Grade 4 bleeding (debilitating blood loss)
- •5\. Palpable Splenomegaly
- •6\. Immunological refractoriness to platelet transfusion
- •7\. Require HLA or HPA matched platelets
- •8\. Pregnant or lactating women
- •9\. Other active malignancy in past 5 years
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
N/A
Platelet reactivity over time in patients undergoing vascular surgeryantiplatelet therapyatherosclerosis10003216NL-OMON46079niversitair Medisch Centrum Utrecht50
Completed
N/A
Platelet reactivity and formation of platelet-monocyte complexes in patients with chronic obstructive pulmonary disease (COPD)COPD chronic obstructive pulmonary disease100110821000643610003216NL-OMON42526ongziekten50
Recruiting
N/A
Effect of platelet rich fibrin on soft tissue thicknessIRCT20200914048713N1Mashhad University of Medical Sciences20
Recruiting
N/A
A Comparative Study of Effects of Platelet-Rich Plasma (PRP) Injection and mixed human acellular dermal matrix (ADM) & PRP Injection in Patients with Lateral Epicondylitis : prospective randomized controlled trialDiseases of the musculoskeletal system and connective tissueKCT0009547The Catholic University of Korea, Yeouido St. Mary's Hospital66
Completed
Phase 4
ASsesment of Platelet function and Inhibition in patients Recovering from severe INfectionAcute myocardial infarctionHeart attack10011082NL-OMON50157Vrije Universiteit Medisch Centrum97