Corticosteroids and Cataracts : Prospective Study of the Impact of Systemic Corticosteroid Therapy on Lens Transparency Evaluated by Scheimpflug Photography and Quantification of Lens Autofluorescence.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Cataracts on Ophthalmologist's Examination
Study Overview
Brief Summary
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.
Detailed Description
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patient who starts a treatment with Prednisone, Prednisolone or Methylprednisolone for an Expected time of one year at least, with normal lens autofluorescence at inclusion.
Exclusion Criteria
- •Previous cataracts and abnormal increase of lens autofluorescence considering age
- •Previous elevation of intraocular pressure
- •Progressive inflammatory or non inflammatory ocular disease
- •Eye drop except artificial tears
- •Insulin dependent and non insulin dependent diabetes
- •Atopic dermatitis
- •Previous protracted corticosteroid therapy
- •Drugs known to be associated with an increased risk of cataract
Outcomes
Primary Outcomes
Cataracts on Ophthalmologist's Examination
Increase of Lens Autofluorescence
Increase of Lens Density on Scheimpflug Photography
Secondary Outcomes
- Potential risk factor of cataracts related to the underlying disease or the individual
- Potential effect of time allowed from the beginning of treatment, duration and dosage of corticosteroids.