NCT00318227已完成不适用
Evaluation of a Liberal Versus Restrictive Blood Transfusion Strategy in Elderly Patients Following Coronary Bypass or Aortic Valve Surgery
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 2
- 主要终点
- Distance walked during 6 minute walk test at 5 weeks postop
研究概览
简要总结
The purpose of this study is to determine whether a less restrictive strategy of red blood cell transfusion in elderly patients following coronary bypass surgery results in enhanced postoperative recovery as determined by quality of life assessment, exercise tolerance and clinical outcomes.
Two postoperative transfusion strategies:
- Liberal - transfused when Hgb is <100g/L
- Restrictive - transfused when Hgb is <70g/L
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 70 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients >=70 years of age undergoing non-emergency coronary artery bypass surgery
- •Initial postoperative hemoglobin level 70-90g/L
排除标准
- •Patients who are unable to provide informed consent in English
- •Patients with preoperative hemoglobin concentrations <100g/L
- •Patients who require emergency re-operation
- •Patients with intraoperative or postoperative bleeding diathesis
- •Patients with postoperative clinical instability (eg. low output state)
- •Patients in whom insertion of an intra-aortic balloon pump is required
研究组 & 干预措施
Liberal Red cell transfusion arm
Active Comparator
Transfusion if Hgb <100g/L
干预措施: Blood Transfusion (Procedure)
Restrictive Red Cell transfusion
Active Comparator
Transfusion if Hgb <70g/L
干预措施: Blood Transfusion (Procedure)
结局指标
主要结局
Distance walked during 6 minute walk test at 5 weeks postop
时间窗: 5 weeks
次要结局
- renal failure, hospital length of stay, Quality of Life questionnaire(during hospital stay)
研究者
研究点 (2)
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