A randomized study on probiotics and their effect on vitamin K2 status

VU University Medical Centre Department of Epidemiology & biostatistics Prof. J. Berkhof, department head0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Higher cardiovascular risk without type 2 diabetes – at least 1 of the following risk factors:
•osystolic blood pressure > 140mm Hg, diastolic blood pressure > 90 mmHg or use of blood pressure lowering medication and/or
•o impaired glucose tolerance
•oFamily history of cardiovascular disease < 65 years
•oTotal cholesterol > 6.5 mmol/l or use of statins
•oSmokers = 50 years
•oEstimated glomerular filtration rate > 30 and < 60 ml/min
•No gastrointestinal tract problems/stool problems
•Written informed consent

•Pregnancy, lactation or a female planning to conceive within the study period
•Any significant medical reason for exclusion as determined by the investigator
•Unable to give written informed consent
•Unable to speak, read and/or write Dutch
•Diabetes of any type.
•Age <50 or = 70 years
•Body mass index < 20 or > 39 kg/m2
•Using vitamin supplements that contain vitamin K, or unwilling to stop two weeks before randomization.
•Using probiotic supplements
•Natto or goose liver consumers
•Use of vitamin K antogonists such as warfarin, acenocoumarol or coumarin derivates
•Use of antibiotics
•Crohn's disease/ Ulcerative Colitis
•Use of more than 3 alcoholic beverages per day

发起方

VU University Medical Centre Department of Epidemiology & biostatistics Prof. J. Berkhof, department head