Investigating Salivary Biomarkers for EarlyChildhood Caries in Autism Spectrum Disorder: AProteomic Analysis.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1. To identify and compare the levels of KRT3
研究概览
简要总结
The onset of ECC can occur as early as the first few years of life, making early detection
and intervention crucial for preventing the progression of the disease.
Recent studies have shown that children with Autism Spectrum Disorder (ASD) are
disproportionately affected by ECC, with factors such as dietary preferences, oral
hygiene difficulties and sensory sensitivities potentially exacerbating their risk. Despite
this, the mechanisms underlying the higher prevalence of ECC in children with ASD
remain poorly understood, and effective diagnostic tools for early detection are
lacking. This study aims to
investigate the potential of salivary biomarkers as indicators for Early Childhood Caries
(ECC) in children diagnosed with Autism Spectrum Disorder (ASD). Specifically, the
study employs analysis to identify and characterize the differences in the salivary
proteome of children with ECC and those without, with a focus on those with ASD.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2.00 Year(s) 至 6.00 Year(s)（—）
- 性别
- All
入选标准
- •Children aged under 6 years Children with Autism Spectrum Disorder Children with def score 3-4.
排除标准
- •Normal children Children with chronic illness/systemic illness Children with orthodontic appliance Children whose parent/guardian doesn’t give written consent.
结局指标
主要结局
1. To identify and compare the levels of KRT3
时间窗: At Baseline
in Autism Spectrum Disorder children with
时间窗: At Baseline
and without Early Childhood Caries.
时间窗: At Baseline
2. To identify and compare the levels of
时间窗: At Baseline
MUC21 in Autism Spectrum Disorder
时间窗: At Baseline
children with and without Early Childhood
时间窗: At Baseline
Caries.
时间窗: At Baseline
次要结局
- 1. To correlate the salivary proteomic findings(along with other salivary parameters (pH)