Clinical Features and Outcome in Patients With Osseomuscular Type of Wilson's Disease

Recruiting

• Conditions: Clinical Features and Outcome

• Registration Number: NCT04965558
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

The investigators aimed to observe the clinical features and outcome in patients with osseomuscular type of Wilson's disease from a large cohort during long-term follow-up

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01-01
• Status Verified: 2021-07
• Study First Submitted: 2021-07-05
• Study First Submitted QC: 2021-07-11
• Last Update Submitted: 2021-07-11
• Study First Posted: 2021-07-16
• Last Update Posted: 2021-07-16
• Primary Completion: 2025-12-01
• Study Completion: 2030-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• genetically diagnosed WD patients

Exclusion Criteria

• Deny follow-up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum ceruloplasmin	From 2004 through 2030	Serum ceruloplasmin levels were collected among patients with wilson disease. After confirming a non-Gaussian distribution, the reference range of serum ceruloplasmin level was determined.
Urinary Copper Excretion	From 2004 through 2030	The measurement of 24-hour urine copper excretions were collected and measured.

Trial Locations

Locations (1)

Second Affiliated Hospital, Zhejiang University School of Medicine; 🇨🇳 Hangzhou, Zhejiang, China