Oxygen Consumption in Post-stroke Patients During Various Walking Activities Compared to Healthy Controls

Not Applicable

Completed

• Conditions: Cerebrovascular Accident
• Interventions: Procedure: walking tasks

• Registration Number: NCT05477238
• Lead Sponsor: University Hospital, Limoges

Brief Summary

Stroke is major public health issue. The investigators recommend post-stroke patients to practice physical activity. Nevertheless, the recommendations are not widely respected due to the intensity of exercises. Oxygen consumption is a parameter to assess the intensity of physical activity. in this sense, we want to measure the oxygen consumption during various walking tasks compared to healthy controls.

Detailed Description

Stroke is defined as an interruption of blood circulation in the brain. The treatments are in first time medical in emergency. Then, the patient will start his rehabilitation with several contributors. At this time, it will recommend physical activity to patients. Regardless of the all benefits of physical activity, it will help patient to avoid a second stroke. The investigators have the recommendations of the high authority of health in physical activity for stroke population. It recommends to practice around 20 to 60 minutes daily of physical activity with moderate effort intensity. Oxygen consumption is a parameter of effort intensity of physical activity measured in ml O2/kg/min. Currently, the investigators have the compendium of physical activity (PA). it allows us to classify PA according to effort intensity. And so, an activity with a moderate effort intensity is an activity between 3 and 5.9 metabolic equivalent task (MET). Note that 1 MET is 3.5 ml/O2/Kg. Nevertheless, this compendium does not correspond to post-stroke individuals. As consequences, Low intensity exercise as described in guidelines might be at a moderate intensity level for stroke survivors. Hence, the investigators want to assess the oxygen consumption of post-stroke individuals during various walking tasks and compare it to healthy controls.

Study Timeline

• Study First Submitted: 2022-06-23
• Study First Submitted QC: 2022-07-25
• Study First Posted: 2022-07-28
• Study Start: 2022-09-07
• Primary Completion: 2023-06-26
• Study Completion: 2023-06-26
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-20
• Last Update Posted: 2023-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Common to both groups:

• Age >=18 years
• Able to give consent
• Not under guardianship or curatorship
• Enrolled in the French social security system

Specific to the cerebrovascular accident Group:

• Stroke confirmed by brain imaging
• Able to walk stairs without human assistance (modified Functional Ambulation Classification >= 6)

Healthy Group Specific:

• Individuals matched to stroke individuals on age sex and BMI.

Exclusion Criteria

Cerebrovascular accident group - Severe cognitive impairment (MoCA < 18)

Common to both groups:

• Presence of contraindication to physical activity: unstable diabetes, unstable hypertension, unstable angina, intra-cardiac thrombus.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
healthy volunteer	walking tasks	Healthy volunteers patients will perform 2 walking tests indoors and outdoors wearing a gas exchange analyzer, an accelerometer and a heart rate monitor meter
Cerebrovascular Accident	walking tasks	Stroke patients will perform 2 walking tests indoors and outdoors wearing a gas exchange analyzer, an accelerometer and a heart rate monitor meter

Primary Outcome Measures

Name	Time	Method
Oxygen consumption measurement	Day 7	Oxygen consumption by indirect calorimetry (respiratory gas exchange analyzer: Metamax) expressed in mL.min-1.kg-1

Secondary Outcome Measures

Name	Time	Method
Total energy expenditure	Day 7	Total energy expenditure during each movement activity estimated by an Actigraph GT3X placed at the healthy ankle
Walking speed measurement	Day 7	Average walking speed measured (distance walked/total time) during different travel activities
Cardiac frequency measurement	Day 7	Average heart rate during activity measured by heart rate meter in bpm
Perception of effort	Day 7	Perception of effort by the Borg scale during the last minute of the movement activity

Trial Locations

Locations (1)

Limoges university hospital; 🇫🇷 Limoges, France