Siewert Type II Esophageal Adenocarcinoma: Relationship Between Histology and Survival

Completed

• Conditions: Siewert Type II Adenocarcinoma of Esophagogastric Junction

• Registration Number: NCT03416101
• Lead Sponsor: University of Bologna

Brief Summary

In Siewert type II adenocarcinoma, the relationship between adenocarcinoma sub types and survival, histologic/biologic patterns related to the presence/absence of gastric greater curvature metastases, were investigated.

Detailed Description

In order to achieve further data on the biological patterns of intestinal and diffuse subtypes of esophageal adenocarcinoma (Lauren's classification), on the frequency of gastric greater curvature nodal stations and on the clinical relevance, in terms of prognosis and survival, of these parameters, a Siewert type II case series of Siewert type II adenocarcinomas, submitted to primary (no neoadjuvant therapy) surgical, studied, operated upon and followed up, were analysed. According to histologic patterns, cases were ordered in intestinal and diffuse adenocarcinoma sub types (Lauren's classification)and distinguished in Barret's, cardiopyloric, gastric types.

Study Timeline

• Study Start: 2007-01-01
• Primary Completion: 2017-06-30
• Study Completion: 2017-06-30
• Status Verified: 2018-01
• Study First Submitted: 2018-01-23
• Study First Submitted QC: 2018-01-23
• Last Update Submitted: 2018-01-23
• Study First Posted: 2018-01-30
• Last Update Posted: 2018-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

Siewert type II adenocarcinoma > 18 year submitted to primary surgery

Exclusion Criteria

Siewert type II adenocarcinoma submitted to neoadjuvant therapy.

Siewert type I adenocarcinoma. Siewert type III adenocarcinoma Squamous Carcinoma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Survival	5 years	5 year survival between intestinal and diffuse types (Lauren's classification) of Siewert type II adenocarcinoma after primary surgery,

Secondary Outcome Measures

Name	Time	Method
Frequency of gastric greater curvature lymph nodes metastases in Siewert II adenocarcinoma	5 years	Frequency of gastric greater curvature lymph nodes metastases and survival

Trial Locations

Locations (2)

Department of Medical and Surgical Sciences University of Bologna; 🇮🇹 Bologna, Bo, Italy

Sandro Mattioli - Alma Mater Studiorum-University; 🇮🇹 Bologna, BO, Italy