Angina in Non Coronary Artery Disease

• Conditions: Angina Pectoris; Microvascular Angina; Angina Pectoris, Variant

• Registration Number: NCT01318629
• Lead Sponsor: Luzerner Kantonsspital

Brief Summary

Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.

Detailed Description

All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).

Study Timeline

• Study Start: 1996-07
• Study First Submitted: 2011-03-17
• Study First Submitted QC: 2011-03-17
• Study First Posted: 2011-03-18
• Status Verified: 2013-04
• Last Update Submitted: 2013-04-16
• Last Update Posted: 2013-04-17
• Primary Completion: 2018-07
• Study Completion: 2018-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 718

Inclusion Criteria

• Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008
• No significant coronary stenoses (no coronary stenoses ≥ 50%)

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Exclusion Criteria

• Severe valvular heart disease
• Severe congestive heart failure

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cause of angina equivalent symptoms in patients with no coronary artery disease	One day
Prognosis of patients with angina equivalent symptoms and normal coronary arteries	10 years after baseline assessment

Trial Locations

Locations (1)

Luzerner Kantonsspital; 🇨🇭 Luzern, Switzerland