Comparison of the effectiveness and safety of hydroxychloroquine and methotrexate in the treatment of moderate to severe oral lichen planus

Department of Pharmacology, Faculty of Medicine, University of Peradeniya0 个研究点开始时间: 待定最近更新: 2024年8月20日

适应症

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•1. Age 18-60 years, both male and female.
•2. Patients with histologically confirmed moderate to severe OLP with or without skin involvement (a pain score of 6 or greater on a VAS of 0 to 10)
•3. Histological confirmation of diagnosis from an incisional biopsy from oral mucosa
•4. Sinhala / English speaking patients

•1. Patients with psychiatric disorders
•2. Pregnant or lactating women (to exclude pregnancy in premenopausal women, treatment will be commenced after the next menstrual period or if still unsure, after a negative urine hCG test.)
•3. Patients with contraindications for HCQ or MTX
•4. Patients with poorly controlled diabetes
•5. Patients with known retinal diseases
•6. Patients with other dermatological conditions in addition to LP
•7. Patients who have received treatment for LP previously
•8. Patients with contraindications to long-term steroids

发起方

Department of Pharmacology, Faculty of Medicine, University of Peradeniya