Effect of Clomiphene Citrate on Uterine Blood Fow in Women With Unexplained Delayed Conception

Completed

• Conditions: Infertility, Female

• Registration Number: NCT03322852
• Lead Sponsor: Cairo University

Brief Summary

In a prospective observational study at a university teaching hospital, blood flow indices and serum hormone levels were compared between spontaneous and stimulated cycles in the same group of 50 patients with unexplained delayed conception.

Detailed Description

In a prospective observational study at a university teaching hospital, the mid-luteal (peri-implantation) endometrial thickness and volume, uterine artery pulsatility index (PI) and resistance index (RI), endometrial and subendometrial vascularization index, flow index, and vascularization flow index, and serum estradiol and progesterone levels were compared between spontaneous and clomiphene citrate stimulated cycles in the same group of 50 patients with unexplained infertility.

Study Timeline

• Study Start: 2014-10-01
• Primary Completion: 2016-10-01
• Study Completion: 2016-10-30
• Status Verified: 2017-10
• Study First Submitted: 2017-10-24
• Study First Submitted QC: 2017-10-24
• Study First Posted: 2017-10-26
• Last Update Submitted: 2017-10-26
• Last Update Posted: 2017-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• Unexplained infertility
• Body mass index less than 30
• Regular menstruation
• Normal pelvic examination and ultrasonography

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Exclusion Criteria

• History of pelvic operations including cesarean section
• History of pelvic inflammatory disease
• Endometriosis
• Pelvic pathology including uterine fibroids
• General disease or medication that could potentially affect pelvic blood flow
• Smoking

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Flow index of the endometrial region	Day 22 to 24 of the menstrual cycle	Flow index of the endometrial region was measured by a researcher

Secondary Outcome Measures

Name	Time	Method
Vascularization index of the endometrial region	Day 22 to 24 of the menstrual cycle	Vascularization index of the endometrial region was measured by a researcher
Vascularization flow index of the endometrial region	Day 22 to 24 of the menstrual cycle	Vascularization flow index of the endometrial region was measured by a researcher
Vascularization index of the sub-endometrial region	Day 22 to 24 of the menstrual cycle	Vascularization index of the sub-endometrial region was measured by a researcher
Flow index of the sub-endometrial region	Day 22 to 24 of the menstrual cycle	Flow index of the sub-endometrial region was measured by a researcher
Vascularization flow index of the sub-endometrial region	Day 22 to 24 of the menstrual cycle	Vascularization flow index of the sub-endometrial region was measured by a researcher

Trial Locations

Locations (1)

Department of Obstetrics and Gynecology, Kasr Al-Ainy hospital, Cairo University; 🇪🇬 Cairo, Greater Cairo, Egypt