ISRCTN17726268已完成不适用
The efficacy and safety of intra-articular injections with the tumour-necrotising factor alpha (TNFa) antagonist infliximab in patients with chronic or recurrent arthritis of the knee
eiden University Medical Centre (LUMC) (The Netherlands)0 个研究点目标入组 40 人开始时间: 2005年12月19日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Inflammatory arthritis involving a knee (rheumatoid arthritis, juvenile chronic arthritis, spondylarthropathies and arthritis of unknown origin)
- •2. Aged above 18 years
- •3. Written informed consent
- •4. At least two therapeutic corticosteroid injections in the affected joint within a period of one year
排除标准
- •1. Haemorrhagic disease
- •2. Arthritis due to infection, gout or osteoarthritis
- •3. Participation in any other study which interferes with or is influenced by this study
- •4. Use of oral prednisone in excess of 10 mg/day
- •5. Recent change of disease modifying anti-inflammatory drug (DMARD) therapy (six weeks or less)
- •6. Intra-articular injection with corticosteroid less than two months ago (concerning all joints)
- •7. Hypersensitivity to methylprednisolone/triamcinolone, lidocain or infliximab (murine proteins) or intravenous (iv) contrast
- •8. Active/latent tuberculosis
- •9. Acute/chronic infection
- •10. Multiple sclerosis
- •11. Decompensation cordis (New York Heart Association [NYHA] classification III and IV)
- •12. Pregnancy or lactating females
- •13. Malignancy
- •14. Claustrophobia
- •15. Pacemaker in situ/metal prostheses and/or vascular clips
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