Effects of Cherry Consumption on Metabolic Health: A Pilot Clinical Study on Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Changes in estimated average glucose
研究概览
简要总结
This study is designed to evaluate the effects of daily sweet cherry consumption on markers of metabolic health in adults. Cherries are rich in bioactive compounds, such as anthocyanins and phenolic acids, which may help reduce oxidative stress, inflammation, and early risk factors for conditions like type 2 diabetes and cardiovascular disease. Participants will consume 280 grams of fresh sweet cherries every day for 42 consecutive days. Blood and urine samples will be collected at four time points: before the intervention (baseline), at day 21, at day 42 (end of the intervention), and two weeks after stopping cherry consumption.
The study will measure changes in blood sugar regulation, markers of inflammation, oxidative stress, liver and kidney function, and immune response. Waist circumference and body mass index will also be recorded.
The aim of this study is to test whether daily cherry consumption can support metabolic health in healthy adults and to provide data that may inform larger and longer clinical trials in the future.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years old
- •Healthy individuals with no known metaboli disorders
排除标准
- •Alcohol consumption
- •Adverse or allergic reaction to cherries
- •Use of antibiotics, anxiolytics, or dietary supplements
- •Pregnancy or lactation
- •Weight changes greater than 10% in the previous year.
研究组 & 干预措施
Daily Sweet Cherry Consumption
Participants in this arm will consume 280 grams of fresh sweet cherries (Prunus avium, "Prime-Giant" variety) every day for 42 consecutive days.
干预措施: Sweet cherries, 280 g daily for 42 days (Dietary Supplement)
结局指标
主要结局
Changes in estimated average glucose
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in fasting glucose
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in HbA1c
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in insulin
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in IL-6
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in gluthatione reductase
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in AGP-1
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in C-reactive protein
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in gluthatione peroxidase
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
Changes in glutamate dehydrogenase
时间窗: Baseline, Day 21, Day 42 and 2 weeks post-intervention
次要结局
- Changes in LDL cholesterol(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in aspartate aminotransferase(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in alanine transaminase(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in gamma-glutamyl transferase(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in total bilirubin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in conjugated bilirubin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in unconjugated bilirubin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in lactate dehydrogenase(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in total proteins(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in albumin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in microalbumin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in urea(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in creatinine(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in TIBC(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in transferrin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in uric acid(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in iron(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in ferritin(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in amylase(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in lipase(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in IgA(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in IgG(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in HDL cholesterol(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in IgM(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in total IgE(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in rheumatoid factor(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in antistreptolysin O(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in triglycerides(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in total cholesterol(Baseline, Day 21, Day 42 and 2 weeks post-intervention)
- Changes in waist circumference(Baseline and Day 42)
- Body Mass Index(Baseline and Day 42)
研究者
Luis Manuel Lopes Rodrigues da Silva
Principal Investigator
Instituto Politécnico da Guarda