Evaluation of clinical and antimicrobial efficacy of chitosan nanoparticle gel (1%) as a local drug delivery in chronic periodontitis patients- a randomised controlled split mouth trial.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- To evaluate the antimicrobial efficacy of Chitosan nanoparticle gel (1%) as local drug delivery against periopathogens Porphyromonas gingivalis, Tanerella forsythia.
研究概览
简要总结
A split mouth study was conducted wherein 29 patients were selected and the results obtained with local drug delivery were compared with those obtained with those obtained with scaling and root planing.Scaling and root planing is the commonly employed procedure for the treatment of periodontal diseases.However tissue invasive bacteria may still be present and harboring the periodontal tissues.Hence the use of adjunctive antimicrobial therapy is advised.There are many commercially available agents for local drug delivery but are associated with disadvantages like antimicrobial resistance, lack of substantivity etc. Chitosan is a drug which once administered will exhibit its effect for extended period of time and hence iwas tried against the periodontal pathogens
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Probing pocket depth 5mm to 8mm.
- •Clinical attachment level of 3mm.
- •Vertical bone loss greater than 3mm on digital radiographs.
排除标准
- •Patients with systemic diseases.
- •Patients who have undergone periodontal treatment in last 6 months.
- •Pregnant and lactating mothers.
结局指标
主要结局
To evaluate the antimicrobial efficacy of Chitosan nanoparticle gel (1%) as local drug delivery against periopathogens Porphyromonas gingivalis, Tanerella forsythia.
时间窗: 6 weeks interval
次要结局
- Gingival index,plaque index,(6 week interval)