Genetic Analysis of Pediatric Psoriasis
Completed
- Conditions
- Psoriasis
- Registration Number
- NCT03768284
- Lead Sponsor
- Northwestern University
- Brief Summary
This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 86
Inclusion Criteria
- Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.
- Parents of patients who developed psoriasis before 12 years of age
- Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.
Exclusion Criteria
- Patients, parents, and other family member unable to give a saliva or buccal swab sample.
- Patients, parents, and other family member unable to give written informed consent.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CARD14 mutations one year The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort
- Secondary Outcome Measures
Name Time Method De novo mutations one year The number of candidate psoriasis genes through the identification of de novo mutations in moderate-to-severe pediatric cases who require systemic intervention.
Trial Locations
- Locations (1)
Ann & Robert H. Lurie Children's Hospital of Chicago
🇺🇸Chicago, Illinois, United States
Ann & Robert H. Lurie Children's Hospital of Chicago🇺🇸Chicago, Illinois, United States