Genetic Analysis of Pediatric Psoriasis

Completed

• Conditions: Psoriasis
• Interventions: Other: Saliva or buccal sample

• Registration Number: NCT03768284
• Lead Sponsor: Northwestern University

Brief Summary

This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2018-10-17
• Study First Submitted: 2018-12-05
• Study First Submitted QC: 2018-12-05
• Study First Posted: 2018-12-07
• Primary Completion: 2021-06-30
• Study Completion: 2021-12-30
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-19
• Last Update Posted: 2022-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.
• Parents of patients who developed psoriasis before 12 years of age
• Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.

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Exclusion Criteria

• Patients, parents, and other family member unable to give a saliva or buccal swab sample.
• Patients, parents, and other family member unable to give written informed consent.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parents of psoriasis patients	Saliva or buccal sample	Parents of patients who developed psoriasis before 12 years of age
Up to third-degree family members with or without psoriasis	Saliva or buccal sample	Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated.
Psoriasis patients	Saliva or buccal sample	Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent.

Primary Outcome Measures

Name	Time	Method
CARD14 mutations	one year	The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort

Secondary Outcome Measures

Name	Time	Method
De novo mutations	one year	The number of candidate psoriasis genes through the identification of de novo mutations in moderate-to-severe pediatric cases who require systemic intervention.

Trial Locations

Locations (1)

Ann & Robert H. Lurie Children's Hospital of Chicago; 🇺🇸 Chicago, Illinois, United States