Prediction of Peritoneal Metastasis for Gastric Cancer Based on Radiomics
Recruiting
- Conditions
- Peritoneal MetastasesGastric Cancer
- Interventions
- Diagnostic Test: Peritoneal metastasis status ascertainment
- Registration Number
- NCT05722275
- Lead Sponsor
- Chinese Academy of Sciences
- Brief Summary
Peritoneal metastasis of gastric cancer is difficult to be detected in time, thus delaying treatment. Based on the conventional CT images of gastric cancer, this study plans to develop, improve and validate an intelligent analysis system based on radiomics. By extracting and combining the radiomics features related to peritoneal metastasis of gastric cancer, the intelligent analysis system could predict the risk of peritoneal metastasis, and provide personalized decision suggestions for the treatment of gastric cancer.
- Detailed Description
Peritoneal metastasis of gastric cancer is difficult to be detected in time, thus delaying treatment. Based on the conventional CT images of gastric cancer, this study plans to develop, improve and validate an intelligent analysis system based on radiomics. By extracting and combining the radiomics features related to peritoneal metastasis of gastric cancer, the intelligent analysis system could predict the risk of peritoneal metastasis, and provide personalized decision suggestions for the treatment of gastric cancer.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
- (1) diagnosed advanced gastric cancer (≥cT3) by endoscopy-biopsy pathology, combined with CT and/or endoscopic ultrasound;
- (2) with both enhanced CT and laparoscopy;
- (3) without typical peritoneal metastasis indications in CT (diffuse omental nodules or omental cake, large amount of ascites, obvious irregular thickening with high peritoneal enhancement);
- (4) without other evidence of distant metastasis, and no stage IV features on CT.
Exclusion Criteria
- (1) previous abdominal surgery;
- (2) previous abdominal malignancies or inflammatory diseases;
- (3) time intervals between CT and laparoscopy longer than 2 weeks;
- (4) CT image artifacts that undermine peritoneal lesion assessment.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Peking University Cancer Hospital & Institute Peritoneal metastasis status ascertainment Peking University Cancer Hospital \& Institute collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Zhenjiang First People's Hospital Peritoneal metastasis status ascertainment Zhenjiang First People's Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Nanfang Hospital of Southern Medical University Peritoneal metastasis status ascertainment Nanfang Hospital of Southern Medical University collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. The First Affiliated Hospital of Zhengzhou University Peritoneal metastasis status ascertainment The First Affiliated Hospital of Zhengzhou University collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Guangdong Provincial People's Hospital Peritoneal metastasis status ascertainment Guangdong Provincial People's Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Shanxi Province Cancer Hospital Peritoneal metastasis status ascertainment Shanxi Province Cancer Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Guizhou Provincial People's Hospital Peritoneal metastasis status ascertainment Guizhou Provincial People's Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Guangzhou Medical University Peritoneal metastasis status ascertainment Affiliated Cancer Hospital and Institute of Guangzhou Medical University collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Fujian Medical University Union Hospital Peritoneal metastasis status ascertainment Fujian Medical University Union Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Sun Yat-sen University Peritoneal metastasis status ascertainment Sun Yat-sen University collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Henan Cancer Hospital Peritoneal metastasis status ascertainment Henan Cancer Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Scientific Institute San Raffaele Peritoneal metastasis status ascertainment Scientific Institute San Raffaele collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status. Yunnan Cancer Hospital Peritoneal metastasis status ascertainment Yunnan Cancer Hospital collects clinical information, preoperative CT images, and the golden standard for peritoneal metastasis status for each patient. Clinical information includes gender, age, gastric disease background, tumor markers, gastric cancer stage, gastric cancer type, treatment program, smoking history, alcohol history, etc. All patients undergo diagnostic laparoscopy. Any suspicious lesion discovered during laparoscopy is biopsied and pathologically examined to determine peritoneal metastasis status.
- Primary Outcome Measures
Name Time Method The aera under the receiver operating characteristic curve (AUC) of intelligent analysis system three months AUC of the intelligent analysis system in predicting peritoneal metastasis for gastric cancer.
- Secondary Outcome Measures
Name Time Method The accuray of intelligent analysis system in predicting peritoneal metastasis three months The agreement between the prediction outcome of intelligent analysis system and the golden standard of peritoneal metastasis.
Trial Locations
- Locations (13)
Scientific Institute San Raffaele
🇮🇹Milan, Italy
Yunnan Cancer Hospital
🇨🇳Kunming, China
Shanxi Province Cancer Hospital
🇨🇳Taiyuan, China
Henan Cancer Hospital
🇨🇳Zhengzhou, China
Zhenjiang First People's Hospital
🇨🇳Zhenjiang, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
Guizhou Provincial People's Hospital
🇨🇳Guiyang, China
Peking University Cancer Hospital & Institute
🇨🇳Beijing, China
Nanfang Hospital of Southern Medical University
🇨🇳Guangzhou, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, China
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
🇨🇳Guangzhou, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, China
Sun Yat-Sen University Cancer Hospital
🇨🇳Guangzhou, China