The Effect of Multiple-Task Training on Physical and Cognitive Functions in Patients With Multiple Sclerosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Gazi University
- Enrollment
- 39
- Locations
- 1
- Primary Endpoint
- cognitive function
Study Overview
Brief Summary
The Activities of Daily Living requires the ability to perform multiple activities at the same time, not just the motor or cognitive activity. When many tasks are performed at the same time, the attention capacity is effectively used and attention is shared according to the difficulty and priority of the tasks. There is evidence that patients with Multiple Sclerosis (MS) have reduced performance during multitasking.
In this study, the investigators aim to investigate the effect of multitasking training on balance, mobility, upper extremity performance and cognitive functions in patients with MS.
Detailed Description
Patients with MS between 0-1,5 score according to the Extended Disability Status Scale (EDSS) will be included in the study. The balance, mobility, upper extremity performance, the cognitive function will be evaluated twice.
The study was designed as a prospective, randomized controlled study. The patients will be randomly assigned to three groups, the "multi-task training (MT)" group, the "single task training (ST)" group, and "control" group. The training will be twice a week for 6 weeks.
Statistical analyses will be performed using the SPSS software version 15 (SPSS Inc. Chicago, IL, USA). The pre-training and post-training measurements of groups will be compared with the Wilcoxon Test. The significance level was set at p< 0.05
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Participants who are ambulatory and volunteer to participate to the study, in a stable phase of the disease, without relapses in the last 3 month, with an EDSS between 0-1,5.
Exclusion Criteria
- •Participants who have orthopedic, vision, hearing, or perception problems
- •Patients who have any cardiovascular or pulmonary disease in which exercise is contraindicated
Arms & Interventions
Single task training
The exercise program consisting of 10 different motor tasks will be implemented in a single task training group.
Intervention: Single task training (Other)
Multi-task training
In the multitasking training group, a second motor task in the first two weeks, a cognitive task in the third and fourth week, both motor and cognitive tasks in the last two weeks will be added to these 10 different motor tasks.
Intervention: Multi-task training (Other)
Control group
The control group will be taught relaxation exercises and will be asked to perform the exercises at home.
Outcomes
Primary Outcomes
cognitive function
Time Frame: thirty minutes
The Brief Repeatable Battery of Neuropsychological Tests
Mobility
Time Frame: ten minutes]
Timed Up and Go Test
Modified Sensory Organization Test
Time Frame: Fifteen minutes]
The Modified Sensory Organization Test, which is performed using computerized posturography, measures postural sway in response to 4 different sensory conditions is measured using a force platform.
Upper extremity function
Time Frame: ten minutes
9-Hole Peg Test
Secondary Outcomes
- Balance Confidence(five minutes)
- Fatigue Severity(Five minutes)
- Physical Activity(ten minutes)
- Fatigue Impact(five minutes)
- Neuropsychological Questionnaire(one minute)
Investigators
Cagla Ozkul
Research Assistant
Gazi University