Comparison of Difference Histamine Concentration (1, 5 and 10 mg/ml) for Positive Control of Skin Prick Test
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Mahidol University
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Mean wheal diameters of SPT of different histamine concentrations.
Study Overview
Brief Summary
Skin prick test (SPT) was used for diagnostic test for type 1 hypersensitivity. The efficacy and safety of SPT were proved. The positive control of SPT is histamine.
In Thailand, the most common concentration of histamine for SPT is 10 mg/ml. However, in some practice they use other concentration (1, 2.5 mg/ml).
This study will find the proper concentration of histamine for positive control use in SPT.
Detailed Description
Appropriate concentration of histamine positive control is important in interpretation the result of skin prick test.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 7 Years to 60 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Parcitipate person who attented allergy clinic, ENT clinic
- •Legible in Thai language
Exclusion Criteria
- •Patient cannot withhold antihistamine drug
- •Pragnancy and lactation mother
- •comorbid disease such as cardiac disease, liver, renal, hypertension and severe asthma
Arms & Interventions
SPT of histamine
SPT of histamine concentration 1, 5 and 10 mg/ml
Intervention: SPT (Procedure)
Outcomes
Primary Outcomes
Mean wheal diameters of SPT of different histamine concentrations.
Time Frame: 1 years
compare mean wheal diameters of histamine concentration 1,5, and 10 mg/ml
Secondary Outcomes
- Mean wheal diameters of SPT of local and imported histamine positive concentration(1 year)
Investigators
Nualanong Visitsunthorn
Prof
Mahidol University