Prognostic Indicators in Pituitary Adenoma Surgery: a Comprehensive Analysis of Surgical Outcomes and Complications.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pituitary Adenoma
- Sponsor
- Central Hospital, Nancy, France
- Enrollment
- 211
- Locations
- 1
- Primary Endpoint
- Risk factors associated with complications
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Predicting the outcome of pituitary surgery, particularly the risk of complications, is a critical determinant in selecting the appropriate treatment modality for patients. To date, only a limited number of risk factors have been identified for complications following pituitary surgery, including tumor size, younger age, and previous surgical intervention. Furthermore, existing studies have demonstrated that prolactin levels can serve as a surrogate marker for assessing pituitary function, specifically revealing associations between elevated prolactin levels and anterior pituitary insufficiencies.
In a retrospective study on the "HYP'OP" cohort, the aim of the study is to identify predictive factors for both surgical outcomes and complications.
Investigators
DEMARQUET Lea
Principal Investigator
Central Hospital, Nancy, France
Eligibility Criteria
Inclusion Criteria
- •Transsphenoidal pituitary surgery at Nancy University Hospital (France) between 2012 and 2022 for a pituitary adenoma.
Exclusion Criteria
- •No 4 month evaluation.
Outcomes
Primary Outcomes
Risk factors associated with complications
Time Frame: Within 6 months after surgery
Risk factors associated with complications arising from surgery, specifically targeting the incidence of de-novo, clinically significant pituitary insufficiencies
Secondary Outcomes
- Factors predictive of the 'success' of surgery(Within 6 months after surgery)
- Is immediate postoperative hypoprolactinemia predictive of the onset of a new, clinically significant hormonal insufficiency?(Within 6 months after surgery)