ow-dose combined oral contraceptives use is associated to lower bone mass in adolescents over a one-year period
Not Applicable
- Conditions
- G11.427.100Bone Mineral Density, Bone Mineral ContentG11.427
- Registration Number
- RBR-5h9b3c
- Lead Sponsor
- Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Julio de Mesquita Filho
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
healthy female volunteers; between 12 and 20 years old; who were post menarche and had regular menstrual cycles; attending the Adolescent Medicine Outpatient Clinic at Botucatu University Hospital from the São Paulo State University -UNESP; not using any type of hormonal contraceptive.
Exclusion Criteria
premature or low birth weight; prolonged steroid treatment; with diabetes mellitus, acute or chronic malnutrition, congenital or acquired bone diseases, gastrointestinal malabsorption, history of nephropathy, endocrinopathies; early or late puberty; chronic drug consumption; use of medication known to negatively affect bone metabolism.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the Bone Mineral Density evaluated with dual-energy X-ray absorptiometry (DXA) using a Hologic QDR 4500 Discovery A apparatus of adolescents using low dose contraceptives with results from healthy adolescents not using contraceptives.;Contraceptives users presented low bone mass acquisition in the lumbar spine bone mineral density with variation percentages between initial and final moments (+2.07%). The control group presented variations (+12.16%) over the same period.
- Secondary Outcome Measures
Name Time Method The use of a low COC dose with Ethinylestradiol 20µg/Desogestrel 150µg was associated to lower bone mass acquisition in adolescents during the study period.