Influence of Daylong Glycemia on Detraining Induced Metabolic Changes

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: soft drinks

• Registration Number: NCT02321033
• Lead Sponsor: University of Hohenheim

Brief Summary

Aim of the study is to investigate the impact of glycemic index (provided as soft drinks) on changes in insulin sensitivity, metabolic flexibility, and arterial stiffness in response to detraining.

The investigators hypothesize that low glycemic soft drinks decrease the detraining-induced impairment of insulin sensitivity, metabolic flexibility and arterial stiffness.

Detailed Description

The duration of the study is 7 weeks: two x 2 weeks intervention (phase A and phase B) with 3 weeks washout phase inbetween. Each 2-week intervention phase consists of an active week followed by an inactive week.

in phase A subjects consume high GI (maltodextrin and sucrose) soft drinks during the inactive week. In phase B subjects consume a low GI soft drink (palatinose) during the inactive week.

subjects were randomly assigned to either start with phase A or with phase B (cross over design).

During the whole study duration all food is provided (55% CHO, 30% fat, 15% protein)

Physical activity will be assessed by a step counter (active phase 7000-10000 steps/d and inactive phase 3000-4000 steps/d).

Study Timeline

• Study Start: 2014-08
• Study First Submitted: 2014-08-21
• Study First Submitted QC: 2014-12-19
• Study First Posted: 2014-12-22
• Primary Completion: 2015-06
• Study Completion: 2015-09
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-17
• Last Update Posted: 2015-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 16

Inclusion Criteria

• normal weight men,
• age 18-35 y,
• active life style,
• > 300 min sports/week

Exclusion Criteria

• food allergies,
• regular use of medication,
• smoking,
• chronic disease,
• vegan/vegetarian diet

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
low glycemic index	soft drinks	palatinose in soft drinks
high glycemic index	soft drinks	sucrose plus maltodextrin in soft drinks

Primary Outcome Measures

Name	Time	Method
Influence of GI on inactivity-induced changes in insulin sensitivity as measured by an OGTT	the difference between the end of each 1 week activity phase (day 7 vs. day 14, low vs. high physical activity) is compared between high GI and low GI intervention	Influence of GI (glycemic index) on detraining-induced changes (difference between the end of high activity and low activity phases) in insulin sensitivity Insulin sensitivity is assessed by HOMA and Matsuda indices

Secondary Outcome Measures

Name	Time	Method
Influence of GI on inactivity-induced changes in metabolic flexibility as measured by indirect calorimetry (RER, respiratory exchange ratio)	the difference between the end of each 1 week activity phase (day 7 vs. day 14) is compared between high GI and low GI intervention	Impact of GI on inactivity induced changes in metabolic flexibility Metabolic flexibility is defined as the body´s ability to adapt fuel oxidation to changing fuel availability and energy demand It is measured as change in fasting RER (fasting metabolic flexibility) and change in RQ (difference between the end of high activity and low activity phases) after an oral glucose tolerance test (postprandial metabolic flexibility)

Trial Locations

Locations (1)

Institute of Nutritional Medicine, University of Hohenheim; 🇩🇪 Stuttgart, Germany