Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Insulin Biosynthesis Rate
研究概览
简要总结
The gut hormone glucagon like peptide-1 (GLP-1) has been shown to have important effects on maintaining the function and health of the insulin producing beta cells. This hormone is known to increase the production rate of new insulin as well as increase the release of insulin into the blood.
详细描述
We will measure the rate of new insulin production in subjects with Type 2 diabetes compared to non diabetic subjects. We hypothesize that subjects with Type 2 diabetes make less insulin in response to GLP-1 compared to non diabetic subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 2 Diabetes
- •Non diabetic
排除标准
- •Currently taking medication such as thiazolidinediones, metformin, Exenatide, or sitagliptin
- •Chronic condition such as chronic heart failure CHF), Coronary Artery Disease (CAD), or chronic renal failure (CRF)
研究组 & 干预措施
Diabetic Group
Participants with Type 2 diabetes
干预措施: glucagon like peptide-1 (Drug)
Diabetic Group
Participants with Type 2 diabetes
干预措施: glucose control (Dietary Supplement)
Non-diabetic Group
Participants who are non-diabetic will serve as control. treatment is matched to experimental group
干预措施: glucagon like peptide-1 (Drug)
Non-diabetic Group
Participants who are non-diabetic will serve as control. treatment is matched to experimental group
干预措施: glucose control (Dietary Supplement)
结局指标
主要结局
Insulin Biosynthesis Rate
时间窗: 24 hours
Blood insulin biosynthesis rate
次要结局
未报告次要终点