Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block

Phase 4

Completed

• Conditions: Upper Extremity Injury Trauma
• Interventions: Procedure: appropriate volume of 0.5% ropivacaine

• Registration Number: NCT01334619
• Lead Sponsor: Beijing Jishuitan Hospital

Brief Summary

The retrograde infraclavicular brachial plexus block has been proved an effective and safe approach. Realtime ultrasound guide will facilitate a successful peripheral nerve block. The purpose of this study was to determine the medium effective volume required to produce an effective retrograde infraclavicular block using an ultrasound (US)-guided technique.

Detailed Description

Thirty adults undergoing elective upper limb surgery received an US-guided retrograde infraclavicular block. The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. The effective volume in 95% of patients (EV95) was calculated using probit regression.

Study Timeline

• Status Verified: 2010-02
• Study Start: 2010-03
• Primary Completion: 2010-04
• Study Completion: 2010-05
• Study First Submitted: 2011-04-07
• Study First Submitted QC: 2011-04-12
• Last Update Submitted: 2011-04-12
• Study First Posted: 2011-04-13
• Last Update Posted: 2011-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Elected upper extremity operations
• BMI 17~30kg/m2
• ASA I/II

Exclusion Criteria

• Infection at injection site
• Sepsis
• Coagulation Dysfunction
• Phrenic nerve palsy
• Pneumothorax
• Recurrent laryngeal nerve palsy
• Clavicle fracture combined with nerve damage

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ropivacaine volume titration	appropriate volume of 0.5% ropivacaine	-

Primary Outcome Measures

Name	Time	Method
VAS of brachial plexus innervated area	20 minutes	effect and side effects of the present block approach for brachial plexus.

Secondary Outcome Measures

Name	Time	Method
medium effective ropivacaine volume	about 2 months	The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. EV95 was calculated using probit regression.

Trial Locations

Locations (1)

Beijing jishuitan hospital; 🇨🇳 Beijing, China