A Phase II Trial of Pazopanib and Durvalumab for Metastatic Soft Tissue Sarcoma
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Objective Response Rate
研究概览
简要总结
Pazopanib is an angiogenesis inhibitor targeting VEGFR-1, -2, and -3; PDGFR-α and -β; and the receptor c-Kit, and is indicated for the treatment of subjects with advanced renal cell carcinoma (RCC) and advanced STS. For this orphan tumor, STS, PD-L1 targeting may be a promising strategy and favorable toxicity may warrant further combination.
详细描述
Pazopanib is an angiogenesis inhibitor targeting VEGFR-1, -2, and -3; PDGFR-α and -β; and the receptor c-Kit, and is indicated for the treatment of subjects with advanced renal cell carcinoma (RCC) and advanced STS. Pro-angiogenic factors suppress various immune functions whereas antiangiogenic agents have potential to modulate the tumor microenvironment and improve immunotherapy. An analysis of patients with RCC treated with pazopanib demonstrated that elevated expression of PD-L1 correlates with shorter PFS. Investigator also identified 43% of PD-L1 expression in STS and PD-L1 expression had worse overall survival (5-year survival rate: 48% in PD-L1 positive vs. 68% in PD-L1 negative, p=0.015). In detail, PD-L1 expression was reported 52.6% in synovial sarcoma, 37.6% in rhabdomyosarcoma, and 100% in epithelioid sarcoma. For this orphan tumor, STS, PD-L1 targeting may be a promising strategy and favorable toxicity may warrant further combination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed STS progression to 1 or 2 prior chemotherapy
- •Age > 18 years at time of study entry.
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- •Measurable disease by Response Evaluation Criteria in Solid Tumors Version 1.1
- •Body weight >30kg
- •Adequate laboratory findings
- •Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients.
- •Patient is willing and able to comply with the protocol for the duration of the study
- •Must have a life expectancy of at least 12 weeks
- •Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
- •Patients with evidence of portal hypertension (including splenomegaly detected radiographically) or any prior history of variceal bleeding must have had endoscopic evaluation within the 3 months immediately prior to enrollment, and the findings do not represent a high bleeding risk.
排除标准
- •More than 4 prior cytotoxic regimens
- •Participation in another clinical study with an investigational product during the last 2 weeks
- •Receipt of the last dose of anticancer therapy 14 days prior to the first dose of study drug
- •Any previous treatment with a PD1 or PD-L1 inhibitor (including durvalumab) and/or pazopanib
- •Mean QT interval corrected for heart rate (QTc) >480 ms calculated from 3 electrocardiograms (ECGs) using Fridericia's Correction
- •Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the exception of alopecia, vitiligo, and the laboratory values defined in the inclusion criteria
- •Any concurrent chemotherapy, biologic, or hormonal therapy for cancer treatment within 2 weeks prior to entering the study. Concurrent use of hormonal therapy for non-cancer-related conditions (e.g., hormone replacement therapy) is acceptable
- •Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 4 weeks of the first dose of study drug
- •Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of IP.
- •History of allogenic organ transplantation.
- •Active or prior documented autoimmune or inflammatory disorders
- •Uncontrolled intercurrent illness
- •History of active infection
- •History of another primary malignancy
- •History of leptomeningeal carcinomatosis who are neurologically unstable or have required active treatment
- •Receipt of live attenuated vaccine within 30 days prior to the first dose of investigational product(IP).
- •Female patients who are pregnant or breastfeeding or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose.
- •Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients.
- •No history of any of the following in the past 6 months: cardiac angioplasty or stenting, myocardial infarction, unstable angina, coronary artery bypass graft surgery, symptomatic peripheral vascular disease class III or IV congestive heart failure, as defined by the New York Heart Association), thromboembolic events
研究组 & 干预措施
durvalumab+pazopanib
Durvalumab 1500mg IV 1hr q3weeks Pazopanib 800mg QD PO q3wwks
干预措施: Durvalumab, pazopanib (Drug)
结局指标
主要结局
Objective Response Rate
时间窗: 12 weeks
antitumor efficacy of durvalumab and pazopanib
次要结局
未报告次要终点