Ischemic Conditioning as an Intervention to Improve Motor Function in Chronic Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 2
- 主要终点
- Leg Muscle Strength
研究概览
简要总结
The investigators will test whether an intervention called ischemic conditioning can improve paretic leg motor function in chronic stroke subjects.
详细描述
This study will study ischemic conditioning (IC) as an intervention to improve motor function post-stroke. IC is a well studied, well tolerated intervention which has been shown to improve regional blood flow, motor neuron excitability and muscle function in multiple patient groups and in young, healthy subjects. Because IC targets three physiological systems which are all affected by stroke, the investigators hypothesize that repeated bouts of IC will result in improved motor function of the paretic leg.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •be between the ages of 18-85
- •able to give informed consent
- •be ≥ 6 months post diagnosis of unilateral cortical stroke and
- •have residual leg paresis.
排除标准
- •chronic low back or hip pain
- •substance abuse
- •head trauma in last 6 months
- •neurodegenerative disorder
- •any uncontrolled medical condition
- •any condition where knee extension contractions are contraindicated
- •people who are unable to follow multi step commands.
- •people who cannot walk ≥ 10 ft without physical assistance.
- •history of major psychiatric disorder
- •participant has had a myocardial infarction in the last year
- •participant has uncontrolled hypertension
- •participant is unable to contract knee muscles
结局指标
主要结局
Leg Muscle Strength
时间窗: Within 1 year of admission into the study
Maximum voluntary contraction of the leg muscles, measured in Newton Meters, as assessed using a Biodex dynamometer.
次要结局
- Brachial Artery Flow Mediated Dilation(Within 1 year of admission into the study)
- Leg Muscle Fatigue(Within 1 year of admission into the study)
研究者
Matthew Durand
Assistant Professor
Medical College of Wisconsin