The relation between free serotonin in plasma, serotonin in trombocytes and the genotype of the serotonin transporter in carcinoid patients, patients on selective serotonin reuptake inhibitors and healthy controls.

Completed

• Conditions: carcinoid tumoren; Carcinoid tumors; depression; mood disorder; serotonin producing tumors; 10027946

• Registration Number: NL-OMON35209
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 105

Inclusion Criteria

Healthy volunteers
Patients with serotonin producing carcinoid tumors
Patients on SSRIs for the treatment of depression

Exclusion Criteria

Subjects on mediation that influences serotonin-metabolisme, such as aspirine, antidepressive medication, MAO-inhibitors or is involved in serotonin reuptake, with the exception of SSRIs in the SSRI group.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Free and stored serotonin and dopamine is measured in plasma and trombocytes,<br /><br>respectively. DNA is isolated form whole blood for genotyping of the serotonine<br /><br>transporter.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>na</p><br>