Clinical Application of Quantitative Ultrasonographic Analysis in Early Kidney Injury

Recruiting

• Conditions: Patient Admitted to Hospital With Acute Kidney Injury Due to Sepsis

• Registration Number: NCT05662774
• Lead Sponsor: Second Affiliated Hospital of Soochow University

Brief Summary

The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).

Detailed Description

Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.

Study Timeline

• Study First Submitted: 2022-11-28
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-15
• Last Update Submitted: 2022-12-15
• Study First Posted: 2022-12-22
• Last Update Posted: 2022-12-22
• Study Start: 2023-01-01
• Primary Completion: 2024-11-30
• Study Completion: 2024-11-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Meets the AKI diagnostic criteria of the Kidney Disease: Improving Global Outcomes (KDIGO)
2. Meets Sepsis 3.0 diagnostic criteria for sepsis: infection + SOFA ≥ 2

Exclusion Criteria

1. Urinary tract obstruction, hydronephrosis, etc.
2. Left ventricular ejection fraction <30% (measured by transthoracic echocardiography), systolic pulmonary artery pressure >90 mmHg (measured by transthoracic echocardiography)
3. Allergy or adverse reaction to contrast media

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ultrasound Doppler parameters	First 24 hours after admission	Relative blood flow（RBF）in L/min
Ultrasonography parameters	First 24 hours after admission	area under curve is the multiplication of acoustic intensity and time（a.u\*s）

Trial Locations

Locations (1)

The Second Hospital of Soochow University; 🇨🇳 Suzhou, Jiangsu, China