The Clinical Application of Ultrasound for Acute Kidney Injury During Sepsis - From Macroscopic to Microscopic Renal Perfusion Perspectives
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Ultrasound Doppler parameters
研究概览
简要总结
The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).
详细描述
Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 19 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets the AKI diagnostic criteria of the Kidney Disease: Improving Global Outcomes (KDIGO)
- •Meets Sepsis 3.0 diagnostic criteria for sepsis: infection + SOFA ≥ 2
排除标准
- •Urinary tract obstruction, hydronephrosis, etc.
- •Left ventricular ejection fraction <30% (measured by transthoracic echocardiography), systolic pulmonary artery pressure >90 mmHg (measured by transthoracic echocardiography)
- •Allergy or adverse reaction to contrast media
结局指标
主要结局
Ultrasound Doppler parameters
时间窗: First 24 hours after admission
Relative blood flow（RBF）in L/min
Ultrasonography parameters
时间窗: First 24 hours after admission
area under curve is the multiplication of acoustic intensity and time（a.u\*s）
次要结局
未报告次要终点