The Clinical Application of Ultrasound for Acute Kidney Injury During Sepsis - From Macroscopic to Microscopic Renal Perfusion Perspectives
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Patient Admitted to Hospital With Acute Kidney Injury Due to Sepsis
- Sponsor
- Second Affiliated Hospital of Soochow University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Ultrasound Doppler parameters
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).
Detailed Description
Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Meets the AKI diagnostic criteria of the Kidney Disease: Improving Global Outcomes (KDIGO)
- •Meets Sepsis 3.0 diagnostic criteria for sepsis: infection + SOFA ≥ 2
Exclusion Criteria
- •Urinary tract obstruction, hydronephrosis, etc.
- •Left ventricular ejection fraction \<30% (measured by transthoracic echocardiography), systolic pulmonary artery pressure \>90 mmHg (measured by transthoracic echocardiography)
- •Allergy or adverse reaction to contrast media
Outcomes
Primary Outcomes
Ultrasound Doppler parameters
Time Frame: First 24 hours after admission
Relative blood flow（RBF）in L/min
Ultrasonography parameters
Time Frame: First 24 hours after admission
area under curve is the multiplication of acoustic intensity and time（a.u\*s）