Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Cognitive performance as modulated by either ginseng or ginkgo biloba
研究概览
简要总结
There is some evidence to suggest that ginseng and Ginkgo biloba can improve cognitive performance, however, very little is known about the mechanisms associated with such improvement. Here, we tested whether cardiovascular reactivity to a task is associated with cognitive improvement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers ranging in age between 18 and 30.
排除标准
- •Ginseng group: exclude those that regularly consume caffeine or Panax Ginseng, or those that are diabetic, have hormone sensitive conditions, autoimmune diseases, bleeding conditions, heart conditions or take medications that are known to interact with Panax Ginseng. These include anticoagulants, Warfarin, Ibuprofen, MAOIs, medications that are changed by the liver, and stimulant drugs (e.g. pseudoephedrine, epinephrine).
- •Ginkgo Biloba group: exclude those that regularly consume caffeine or Ginkgo Biloba, or those that are diabetic, have experienced seizures in the past, have bleeding disorders, or take medications that are known to interact with Ginkgo Biloba. These include Ibuprofen, anticoagulants, Warfarin, Buspirone, Fluoxetine, Trazodone
研究组 & 干预措施
Placebo
Study subjects received, in a double blind fashion, placebo pills identical to the drug (ginseng: group 1; ginkgo biloba: group 2).
干预措施: Placebo (Drug)
Placebo
Study subjects received, in a double blind fashion, placebo pills identical to the drug (ginseng: group 1; ginkgo biloba: group 2).
干预措施: Ginseng (Drug)
Placebo
Study subjects received, in a double blind fashion, placebo pills identical to the drug (ginseng: group 1; ginkgo biloba: group 2).
干预措施: Ginkgo Biloba (Drug)
Ginseng
Participants in the ginseng group received a medium, and higher dose of ginseng in addition to placebo capsules.
干预措施: Placebo (Drug)
Ginseng
Participants in the ginseng group received a medium, and higher dose of ginseng in addition to placebo capsules.
干预措施: Ginseng (Drug)
Ginkgo Biloba
Participants in the ginkgo biloba group received a medium, and higher dose of ginkgo in addition to placebo capsules.
干预措施: Placebo (Drug)
Ginkgo Biloba
Participants in the ginkgo biloba group received a medium, and higher dose of ginkgo in addition to placebo capsules.
干预措施: Ginkgo Biloba (Drug)
结局指标
主要结局
Cognitive performance as modulated by either ginseng or ginkgo biloba
时间窗: Acute effects (3 days of testing)
Cognitive effects on tests of vigilance/attention, behavioural flexibility and executive functioning
次要结局
- Cardiovascular reactivity as a result of ginseng or ginkgo biloba intake(Acute effects (3 days of testing))
研究者
Dr. Luca Aquili
Dr. Luca Aquili
Sunway University