NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients

Not Applicable

Completed

• Conditions: Mechanical Ventilation Complication; High-flow Oxygenation; Weaning Failure; Acute Respiratory Distress Syndrome
• Interventions: Device: Respiratory support

• Registration Number: NCT06332768
• Lead Sponsor: Northern State Medical University

Brief Summary

The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory support.

Detailed Description

HFNO (high-flow nasal oxygenation and NIV (non invasive ventilation) are to be randomly compared in the ARDS postextubation period.

Study Timeline

• Study Start: 2017-09-01
• Primary Completion: 2022-01-01
• Study Completion: 2022-03-01
• Status Verified: 2024-03
• Study First Submitted: 2024-03-20
• Study First Submitted QC: 2024-03-20
• Last Update Submitted: 2024-03-20
• Study First Posted: 2024-03-27
• Last Update Posted: 2024-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ARDS

Exclusion Criteria

Severe ICU-aquired weakness Severe COPD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
NIV	Respiratory support	Non-invasive ventilation
HFO	Respiratory support	High Flow Oxygenation

Primary Outcome Measures

Name	Time	Method
Weaning failure	48 hrs	Weaning failure and re-intubation or recanulation

Trial Locations

Locations (1)

City hospital # 1; 🇷🇺 Arkhangelsk, Arkhangelsk Region, Russian Federation