Risk Factors for Falls and Fall-related Injuries Associated With Mild Neurocognitive Disorders

Active, not recruiting

• Conditions: Old Age; Fall Injury; Neurocognitive Disorders

• Registration Number: NCT03978650
• Lead Sponsor: Jewish General Hospital

Brief Summary

This study evaluates the risk for incident falls and fall-related injuries at the onset of neurocognitive disorders in older adults participating in the Canadian Longitudinal Study

Detailed Description

Falls are frequent events in adults over age 65 (up to 30% each year in Canada). They are a major Canadian public health concern, which negatively impacts health and quality of life of fallers, and health care system. Neurocognitive disorders are strongly associated with falls and fall-related injuries.

Several clinical characteristics, identified previously as risk factors for falls in the older population and in older adults with neurocognitive disorders are selected in the Canadian Longitudinal Study On Aging. The performance criteria of different statistical models will be compared for the association of neurocognitive disorders with falls and fall-related injuries. Six linear statistical models (i.e., logistic regression, discriminant analysis, Bayes network algorithm, decision tree, random forest, boosted trees), Factor Mixture Models and two different artificial neural network (i.e., multilayer perceptron and the neuroevolution of augmenting topologies).

Study Timeline

• Study First Submitted: 2019-06-04
• Study First Submitted QC: 2019-06-06
• Study First Posted: 2019-06-07
• Study Start: 2019-07-23
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-22
• Last Update Posted: 2024-02-23
• Primary Completion: 2025-08-01
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 12000

Inclusion Criteria

• People who are 65 years and over
• Men and women who live in Canada

Exclusion Criteria

• People who do not live in Canada
• A fall resulting from acute medical event and/or an external factor
• Moderate to severe dementia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fall Injury	18 months	Incident falls occurring during the 18 months. Information related fall- injuries will also be collected, including fractures, dislocations, voluminous intracranial or peripheral hematomas, trauma of the face, and cutaneous lacerations of significant size and/or deeper than the hypodermis, possibly resulting in medical consultation or hospitalization.

Secondary Outcome Measures

Name	Time	Method
The Mental Alteration Test	around 20 years	Investigator will evaluate the amnesia
Auditory verbal memory disorder	around 20 years	Investigator will use the Rey Auditory Verbal Test that evaluates the auditory-verbal memory.

Trial Locations

Locations (1)

Jewish General Hospital; 🇨🇦 Montréal, Quebec, Canada