Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease

Not Applicable

Completed

• Conditions: Parkinson Disease; Executive Dysfunction
• Interventions: Device: Computer-based cognitive training

• Registration Number: NCT03285347
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The current study adresses the effect of two different computer-based cognitive trianing programmes on attention and executive functions in patients with Parkinson's disease.

Detailed Description

The current study adresses the effect of two different computer-based cognitive training programmes (Brain+ Evolution and Scientific Brain Training PRO) on attention and executive functions in patients with Parkinson's disease. The patients are assigned to one of three groups. Two training groups with each their programme, and a control Group. The training groups will train at home for 8 weeks with follow-ups every second week. The control group will not train at home, but will also receive a follow-up with computer-based stimuli (computerized Card game) every second week, to minimize the possibility that a possible effect is due to the follow-up's with a professional, and not due to the computer training at home.

Study Timeline

• Study First Submitted: 2017-09-14
• Study First Submitted QC: 2017-09-14
• Study First Posted: 2017-09-18
• Study Start: 2017-10-01
• Primary Completion: 2020-02-29
• Study Completion: 2020-06-30
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-25
• Last Update Posted: 2021-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with Parkinson's disease AND
• Montreal cognitive assesment (MOCA)-score between 22-28
• Motorically cabable of using an iPad
• Not receiving antipsychotic medicine
• No comorbid diseases which might influence the level of executive functioning, for an example ADHD or acquired brain damage

Exclusion Criteria

• People without Parkinson's disease
• Parkinson's patients not included in the above inclusion criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Brain+ Evolution	Computer-based cognitive training	Intervention: Training with computer-based programme Brain+ Evolution for 8 weeks, receiving follow-ups every second week. Computer-based cognitive training.
Scientific Brain Training PRO	Computer-based cognitive training	Intervention: Training with computer-based programme Scientific Brain Training PRO for 8 weeks, receiving follow-ups every second week. Computer-based cognitive training.

Primary Outcome Measures

Name	Time	Method
SDMT	2 minutes	Symbol digit modalities test, neuropsychological test of processing speed
PDQ-39	20 minutes	Parkinson's disease questionnaire; daily functioning and well-being in Parkinson's disease

Secondary Outcome Measures

Name	Time	Method
Stroop colour/word test	3 minutes	Stroop colour/Word test, respone inhibition
Trail Making A and B	5 minutes	Trail Making A and B, cognitive flexibility
HADS	10 minutes	Hospital anxiety and depression screening
Digit span	10 minutes	Digit span Wais-IV; Working memory
Verbal fluency	3 minutes	S-Words, animal-names and A/F-words

Trial Locations

Locations (1)

Bispebjerg Hospital; 🇩🇰 Copenhagen, Region Hovedstaden, Denmark