Relevance of Biomarkers in the Process of Weaning

• Conditions: Duration of Weaning

• Registration Number: NCT01341561
• Lead Sponsor: Heidelberg University

Brief Summary

The purpose of the study is to examine the relevance of biochemical markers (specific pulmonary and cardiac markers and markers of endogenous stress) in the process of weaning in patients with artificial ventilation.

Detailed Description

Artificially ventilated patients on our intensive care unit will be monitored if specific biomarkers have a relevance in risk stratification, optimizing therapy, outcome and success in the process of weaning. Therefore, consecutively, specific blood parameters will be taken at time of intubation,day 1 of weaning and extubation.

Study Timeline

• Status Verified: 2011-03
• Study Start: 2011-04
• Study First Submitted: 2011-04-13
• Study First Submitted QC: 2011-04-22
• Last Update Submitted: 2011-04-22
• Study First Posted: 2011-04-25
• Last Update Posted: 2011-04-25
• Primary Completion: 2012-04
• Study Completion: 2013-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Written informed consent
• Able and willing to understand the protocol
• At least 18 years or older

Exclusion Criteria

• Not fulfilling inclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
success of weaning	participants will be followed for the duration of hospital stay, an expected average of 30days	primary outcome measure is the success of weaning during hospital stay. Duration of hospital stay is estimated between 1-60days, in average 30days. Criteria is spontaneous breathing.

Secondary Outcome Measures

Name	Time	Method
follow up	12 months	Follow up is done after 12 months to check major adverse cardiac or pulmonary events (death, myocardial infarction, re-hospitalisation)

Trial Locations

Locations (1)

Intensive Care Unit, University of Heidelberg; 🇩🇪 Heidelberg, Baden-Württemberg, Germany