In patients having shoulder replacement surgeries, is there any difference in giving tranexamic acid orally or intravenously for minimising bleeding during surgery?

Phase 4

Recruiting

• Conditions: Shoulder Arthritis; Osteoarthritis; Musculoskeletal - Osteoarthritis; Surgery - Other surgery

• Registration Number: ACTRN12617000918325
• Lead Sponsor: Whangarei Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-22
• Last Update Posted: 27 July 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Patients undergoing elective shoulder replacements for osteoarthritis

Exclusion Criteria

Patients <18 years of age
Revision surgery
History of joint infection
History of bleeding or metabolic disorder
History of renal failure
History of renal transplant
History of myocardial infarction or stroke within the past year
Placement of an arterial stent within the past year
Preoperative haemoglobin level of <115g/L or haematocrit <35%
History of deep venous thrombosis (DVT) or pulmonary embolism (PE)
Patients unwilling to accept blood transfusion
Patients with allergy to TXA

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Haemoglobin.<br>This is defined as the preoperative haemoglobin minus the lowest postoperative haemoglobin. <br><br>Blood samples will be obtained to gain knowledge of the haemoglobin level (as part of the Full blood count analysis).[All patients will have routine pre-operative haemoglobin on the day of surgery and on each morning during hospital stay post surgery]

Secondary Outcome Measures

Name	Time	Method
Drain output as measured by the volume in the drain once it is removed on the morning of postoperative day one. <br>[morning of the post operative day one.];Number of blood units transfused[As measured by going through clinical records. This is assessed during the operative period and throughout the patient's stay as inpatient following the shoulder arthroplasty.];Length of hospital stay as measured by going through clinical records[Assessed by going through hospital record at the time of hospital discharge.];Incidence of thromboembolic events[During the entire hospital stay.];Calculated blood loss using patient's blood test results before and after the operation during their hospital stay.[Determined during the patient's hospital stay from surgery completion until hospital discharge.];Calculated haemoglobin loss using patient's blood test results before and after the operation during their hospital stay.[Determined during the patient's hospital stay from surgery completion until hospital discharge.]