Double-blind Randomized controlled Trial of Efficiency of NonsteroidalAnti-inflammatory Drugs, Ibuprofen and Mefenamic acid in the Control of peroperative and postoperative endodontic pain.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- reduction in pain noted
研究概览
简要总结
The present clinical trial aimed to compare and evaluate the effectiveness of ibuprofen and mefenamic acid on preoperative and postoperative endodontic pain. Methods: The inclusion criteria are moderate to severe pain of irreversible pulpitis, by using the Visual analogue scale, on mandibular molar teeth, as well as the absence of signs and symptoms of any periapical lesion. two drugs will be compared, the ibuprofen group will receive single dose of combine ibuprofen/paracetamol and mefenamic acid group will receive single dose of combine mefenamic acid/paracetamol. Pain intensity will be measured using visual analogue scale, preoperatively, at one hour after administration of analgesic followed by single visit root canal treatment and measurement of pain intensity at 2 hour and 6 hour.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 15.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient having Spontaneous pain 2)Patient with Pain of endodontic origin.
- •No apparent periapical lesion according to radiographic image.
- •Presented with American Society of Anesthesiologists I or II medical history 5)Read and understood the pain score level sheet.
排除标准
- •Patient younger than 15 years of age.
- •Analgesic taken within last 6 hrs.
- •Pregnant and lactating patients.
- •History of allergy to NSAIDs, aspirin or local anesthetic.
- •Patient currently taking opioids, monoamine oxidase inhibitors, tricyclic antidepressant.
结局指标
主要结局
reduction in pain noted
时间窗: 8 hours
次要结局
- mepheemic acid shows good analgesic effect(8 hours)