Cancer Biology of Retinoblastoma
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Stanford University
- Enrollment
- 8
- Locations
- 2
- Primary Endpoint
- Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations
Study Overview
Brief Summary
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- — to 5 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patient must have retinoblastoma
- •Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care.
- •Parental consent
Exclusion Criteria
- •Diagnosis other than Retinoblastoma
- •No surgical sampling of tumor is planned as part of standard care
- •Parental preference to not participate.
Outcomes
Primary Outcomes
Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations
Time Frame: After appropriate time, e.g., 7, 10, 14 days after reprogramming
Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.
Secondary Outcomes
No secondary outcomes reported