High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome
Phase 1
Completed
- Conditions
- Tourette's Syndrome
- Registration Number
- NCT00139308
- Lead Sponsor
- Groupe Hospitalier Pitie-Salpetriere
- Brief Summary
Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Tourette's syndrome (DSM IV)
- inducing a disability in the social and personal life
- No improvement with medical treatment
- Severe self suffering
Exclusion Criteria
- Cognitive impairment (MMS < 24)
- Depression
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Severity of tics
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere
🇫🇷Paris, France
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere🇫🇷Paris, France